糖尿病中的胰岛素样生长因子（IGF）-I与IGF结合蛋白轴
Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus.
作者信息
Kim Min Sun, Lee Dae-Yeol
机构信息
Department of Pediatrics, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea.
出版信息
Ann Pediatr Endocrinol Metab. 2015 Jun;20(2):69-73. doi: 10.6065/apem.2015.20.2.69. Epub 2015 Jun 30.
Abstract
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
摘要
越来越多的证据表明，胰岛素样生长因子（IGF）-IGF结合蛋白（IGFBP）轴在维持正常的葡萄糖和脂质代谢中起着重要作用。响应糖尿病环境，局部IGF-I-IGFBPs环境会发生显著变化。在1型糖尿病（T1DM）患者中观察到血清IGF-I水平显著降低。相反，在包括T2DM在内的糖耐量异常个体中，检测到血清IGF-I和IGFBP-3水平显著升高。最近，几项前瞻性研究表明，IGF-I和IGFBPs的基线水平与糖尿病的发生有关。这些发现表明，胰岛素和IGF-I-IGFBP轴的紊乱会影响包括糖尿病在内的糖耐量异常的发生。
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