Juhasz Gabriella, Zsombok Terezia, Laszik Andras, Gonda Xenia, Sotonyi Peter, Faludi Gabor, Bagdy Gyorgy
Laboratory of Neurochemistry and Experimental Medicine, and Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Budapest, Hungary.
J Neurogenet. 2003 Apr-Sep;17(2-3):231-40.
It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. There is evidence to suggest that serotonin-related genes participate in the pathogenesis of migraine. Previous studies have shown that gender differences influence the serotonergic neurotransmission and, in addition, the migraine prevalence is higher in females than males. Therefore, we investigated the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the 102T/C polymorphism of the 5-HT2A receptor gene in the Hungarian female population. These genes were analysed in 126 migraine sufferers (with or without aura)and 101 unrelated healthy controls using case control design. A borderline association (chi2 = 3.84, df = 1, p = 0.049; OR = 1.45, 95% CI = 1.00-2.12) between 5-HTTLPR short (S) allele and migraine was found. No significant difference between migraine sufferers and controls was observed for the 102T/C polymorphism of 5-HT2A receptor gene. Furthermore, there was no significant interaction between5-HTTLPR and 102T/C polymorphisms in our study population. In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene.
众所周知，偏头痛具有很强的遗传成分，尽管涉及的基因类型和数量尚不清楚。有证据表明，与血清素相关的基因参与了偏头痛的发病机制。先前的研究表明，性别差异会影响血清素能神经传递，此外，女性偏头痛的患病率高于男性。因此，我们在匈牙利女性人群中研究了血清素转运体基因（5-HTTLPR）上游调控区域的功能多态性以及5-HT2A受体基因的102T/C多态性。采用病例对照设计，对126名偏头痛患者（有或无先兆）和101名无关健康对照者的这些基因进行了分析。发现5-HTTLPR短（S）等位基因与偏头痛之间存在临界关联（χ2 = 3.84，自由度 = 1，p = 0.049；OR = 1.45，95%置信区间 = 1.00 - 2.12）。对于5-HT2A受体基因的102T/C多态性，偏头痛患者与对照组之间未观察到显著差异。此外，在我们的研究人群中，5-HTTLPR和102T/C多态性之间没有显著的相互作用。总之，我们的结果支持偏头痛的遗传易感性可能与5-HT转运体基因或其附近的一个位点有关。
