Ito Toshimitsu
Medical Branch, Ground Service Office, JDA, Tokyo, Japan.
Drug News Perspect. 2003 Oct;16(8):490-2. doi: 10.1358/dnp.2003.16.8.829346.
Since ATP-binding cassette transporter A1 (ABCA1) was discovered as the cause of Tangier disease and familial high-density lipoprotein (HDL) deficiency, many investigators have been interested in the relationship between ABC transporters and the mechanism underlying abnormal lipid metabolism. ABCG1 is an ABC half transporter that facilitates efflux excess cholesterol from macrophages. To elucidate the potential physiological role of ABCG1, we have initiated a series of studies overexpressing ABCG1, using an adenovirus vector (rABCG1-Adv) in C57BL mice. Overexpression of ABCG1 in the liver of mice using recombinant ABCG1 vectors results in decreased plasma HDL levels and increased biliary cholesterol excretion, and indicates that ABCG1 can modulate plasma lipoprotein levels in vivo. ABCG1 and the other ABC transporters might play an important role in cholesterol homeostasis, especially in the liver.
自ATP结合盒转运蛋白A1（ABCA1）被发现是丹吉尔病和家族性高密度脂蛋白（HDL）缺乏症的病因以来，许多研究人员对ABC转运蛋白与脂质代谢异常潜在机制之间的关系产生了兴趣。ABCG1是一种ABC半转运蛋白，可促进巨噬细胞中过量胆固醇的流出。为了阐明ABCG1的潜在生理作用，我们使用腺病毒载体（rABCG1-Adv）在C57BL小鼠中启动了一系列过表达ABCG1的研究。使用重组ABCG1载体在小鼠肝脏中过表达ABCG1会导致血浆HDL水平降低和胆汁胆固醇排泄增加，这表明ABCG1可以在体内调节血浆脂蛋白水平。ABCG1和其他ABC转运蛋白可能在胆固醇稳态中发挥重要作用，尤其是在肝脏中。
