Djeha A, Pérez-Arellano J L, Hayes S L, Brock J H
Department of Immunology, Western Infirmary, Glasgow, UK.
FEMS Microbiol Immunol. 1992 Dec;5(5-6):279-82. doi: 10.1111/j.1574-6968.1992.tb05912.x.
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.
我们已经研究了人和小鼠的淋巴细胞及髓细胞中转铁蛋白的合成。结果发现，转铁蛋白的合成是小鼠巨噬细胞而非人巨噬细胞的特性，而在人类中，T淋巴细胞可合成转铁蛋白。小鼠巨噬细胞的合成对γ干扰素（γ-IFN）呈剂量依赖性增加，但添加的次氮基三乙酸铁没有效果。发现巨噬细胞衍生的转铁蛋白已结合铁，并且能够支持伴刀豆球蛋白A刺激的小鼠淋巴细胞增殖。
