[波兰北部9个Y染色体短串联重复序列位点的群体遗传学]

[Population genetics of 9 Y-chromosome STR loci w Northern Poland].

作者信息

Pawłowski R, Dettlaff-Kakol A, Maciejewska A, Paszkowska R, Reichert M, Jezierski G

机构信息

Katedry i Zakładu Medycyny Sadowej AM w Gdańsku.

出版信息

Arch Med Sadowej Kryminol. 2002 Oct-Dec;52(4):261-77.

PMID:14669672

Abstract

A total of 508 unrelated males from the North Poland population were analyzed for 9 Y-chromosome STRs (DYS 19, DYS 390, DYS 393, DYS 392, DYS 391, DYS 389I, DYS 389II and DYS 385I/II) using two multiplex reactions and detection of PCR products using capillary electrophoresis. In the analyzed sample 328 different haplotypes were identified, among which 264 were unique. It was found that the model for a Polish population haplotype (DYS 1917, DYS 39025, DYS 39313, DYS 39211, DYS 39110, DYS 389I13, DYS 389II30, DYS 385I/II10,14) is almost 15 times more frequent in our population than in a cumulative European one. The haplotype diversity/discrimination index calculated for 9 loci is 0.9943. In the analysed population sample three mutations were detected in the DYS19 (duplication) and DYS385I/II loci (triplications).

摘要

利用两种复合扩增反应和毛细管电泳检测PCR产物，对来自波兰北部人群的508名无血缘关系的男性进行了9个Y染色体短串联重复序列（DYS 19、DYS 390、DYS 393、DYS 392、DYS 391、DYS 389I、DYS 389II和DYS 385I/II）的分析。在分析的样本中，鉴定出328种不同的单倍型，其中264种是独特的。研究发现，波兰人群单倍型模型（DYS 1917、DYS 39025、DYS 39313、DYS 39211、DYS 39110、DYS 389I13、DYS 389II30、DYS 385I/II10,14）在我们的人群中的出现频率几乎是欧洲累计人群的15倍。9个位点计算的单倍型多样性/鉴别指数为0.9943。在分析的人群样本中，在DYS19（重复）和DYS385I/II位点（三倍体）检测到三个突变。