确定重组炭疽疫苗在兔体内的血清学保护相关指标。
Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine.
作者信息
Little S F, Ivins B E, Fellows P F, Pitt M L M, Norris S L W, Andrews G P
机构信息
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702-5011, USA.
出版信息
Vaccine. 2004 Jan 2;22(3-4):422-30. doi: 10.1016/j.vaccine.2003.07.004.
In these studies, a serological correlate of protection against anthrax was identified in New Zealand white (NZW) rabbits that had been given one or two injections of various amounts of recombinant protective antigen (rPA) combined with aluminum hydroxide adjuvant (Alhydrogel). Rabbits were subsequently challenged by the aerosol route with spores of the Ames isolate of Bacillus anthracis. Results suggested that the antibody response, as determined by the quantitative anti-rPA IgG ELISA and toxin neutralizing antibody (TNA) assay, were significant predictors (P<0.0015) of protection against a B. anthracis aerosol spore challenge in rabbits.
在这些研究中，在接受了一或两次不同剂量重组保护性抗原（rPA）与氢氧化铝佐剂（Alhydrogel）联合注射的新西兰白兔（NZW）中，确定了一种针对炭疽的血清学保护相关性。随后，通过气溶胶途径用炭疽芽孢杆菌Ames分离株的孢子对兔子进行攻击。结果表明，通过定量抗rPA IgG ELISA和毒素中和抗体（TNA）测定所确定的抗体反应，是兔子抵抗炭疽芽孢杆菌气溶胶孢子攻击的显著预测指标（P<0.0015）。
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