小于胎龄儿出生儿童的X综合征后遗症。
Sequelae of syndrome X in children born small for gestational age.
作者信息
Veening Margreet A, van Weissenbruch Mirjam M, Delemarre-van de Waal Henriette A
机构信息
Department of Pediatrics, Research Institute for Endocrinology, Reproduction and Metabolism, VU University Medical Center (VUmc), Amsterdam, The Netherlands.
出版信息
Horm Res. 2004;61(3):103-7. doi: 10.1159/000075373. Epub 2003 Dec 10.
OBJECTIVE
Low birth weight is associated with the presence of syndrome X in adults. We studied the components of this syndrome in prepubertal children born SGA (small for gestational age) and children born AGA (appropriate for gestational age).
METHODS
Twenty-nine SGA children, age (mean +/- SD) 9.1 +/- 1.1 years and 24 AGA children, age 9.0 +/- 1.1 years were studied. Fasting serum lipid concentrations were determined. A hyperinsulinemic euglycemic clamp was performed to measure insulin sensitivity. Ambulatory monitoring was performed to obtain 24-hour recordings of blood pressure.
RESULTS
Prepubertal SGA children are less insulin sensitive and have a higher nighttime systolic blood pressure (SBP) after correction for BMI than children born AGA. No differences were found in lipid concentrations between the 2 groups.
CONCLUSIONS
Not all components of syndrome X can yet be found in 9-year-old children born SGA; follow-up of this cohort is required.
目的
低出生体重与成人代谢综合征X的存在有关。我们研究了小于胎龄儿（SGA）和适于胎龄儿（AGA）出生的青春期前儿童中该综合征的组成部分。
方法
研究了29名SGA儿童，年龄（均值±标准差）为9.1±1.1岁，以及24名AGA儿童，年龄为9.0±1.1岁。测定空腹血清脂质浓度。进行高胰岛素正葡萄糖钳夹试验以测量胰岛素敏感性。进行动态监测以获取24小时血压记录。
结果
与AGA出生的儿童相比，青春期前SGA儿童胰岛素敏感性较低，校正BMI后夜间收缩压（SBP）较高。两组之间脂质浓度未发现差异。
结论
在SGA出生的9岁儿童中尚未发现代谢综合征X的所有组成部分；需要对该队列进行随访。
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