de Jong Miranda, Cranendonk Anneke, van Weissenbruch Mirjam M
Department of Pediatrics, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
Department of Pediatrics, Division of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.
Pediatr Res. 2015 Oct;78(4):457-61. doi: 10.1038/pr.2015.118. Epub 2015 Jun 18.
Term small-for-gestational-age (SGA) and preterm born infants have an increased prevalence of metabolic syndrome components already in childhood. Our recent study in 2-y-old very-low-birth-weight (VLBW) infants was limited by the absence of a control group of term born children. We compared the metabolic syndrome components in early childhood in VLBW and term SGA infants to term appropriate for gestational age (AGA) infants.
We included 38 VLBW children and 82 term born children (64 AGA/18 SGA). HDL cholesterol, triglycerides, glucose, and insulin were measured in blood samples taken at 1 y (term children) and 2 y (all children) of (corrected) age.
At 2 y corrected age, VLBW children have lower BMI and higher glucose level compared to AGA children. SGA children have lower BMI at 1 and 2 y of age and a high prevalence of high triglyceride levels at 1 y of age compared to AGA children. Total body fat is a significant determinant of HDL cholesterol and triglycerides and birth weight is a significant determinant of glucose at 2 y corrected age.
In early childhood, VLBW and term SGA children already have a high prevalence of some metabolic syndrome components compared to term AGA children.
足月小于胎龄（SGA）和早产出生的婴儿在儿童期代谢综合征各组分的患病率就已升高。我们最近针对2岁极低出生体重（VLBW）婴儿开展的研究因缺乏足月儿对照组而受到限制。我们比较了VLBW婴儿、足月SGA婴儿与足月适于胎龄（AGA）婴儿在儿童早期的代谢综合征各组分情况。
我们纳入了38名VLBW儿童和82名足月儿（64名AGA/18名SGA）。在（矫正）年龄1岁（足月儿）和2岁（所有儿童）时采集血样，测定血样中的高密度脂蛋白胆固醇、甘油三酯、葡萄糖和胰岛素水平。
在矫正年龄2岁时，与AGA儿童相比，VLBW儿童的体重指数（BMI）更低，血糖水平更高。与AGA儿童相比，SGA儿童在1岁和2岁时BMI更低，且在1岁时高甘油三酯水平的患病率更高。在矫正年龄2岁时，全身脂肪是高密度脂蛋白胆固醇和甘油三酯的重要决定因素，出生体重是血糖的重要决定因素。
在儿童早期，与足月AGA儿童相比，VLBW和足月SGA儿童已经有较高的一些代谢综合征组分患病率。
