Kato Karen, Omori So, Tanaka Takanao, Komatsu Sunao, Seo Takashi, Sugimura Jun, Konda Ryuichirou, Yamazaki Etsuko, Fujioka Tomoaki
Department of Urology, Iwate University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 2003 Nov;94(7):701-4. doi: 10.5980/jpnjurol1989.94.701.
Interferon alpha (IFN-alpha) therapy was conducted for a male patient aged 70 years old, who underwent a two-stage radical nephrectomy for bilateral renal cell carcinoma with multiple pulmonary metastasis. He was hospitalized due to leg weakness and disorientation 45 days after this treatment was started. We discontinued INF-alpha therapy immediately after neurologists indicated the disorder of the central and the peripheral nervous systems induced by the administration of this cytokine. Steroid pulse therapy was effective to resolve the patient's neurological symptoms. To our knowledge, this is the first case of the side effects on both central and peripheral nervous systems by IFN-alpha therapy for renal cell carcinoma.
对一名70岁男性患者进行了α干扰素（IFN-α）治疗，该患者因双侧肾细胞癌伴多发肺转移接受了两阶段根治性肾切除术。在开始这种治疗45天后，他因腿部无力和定向障碍住院。在神经科医生指出这种细胞因子给药引起中枢和周围神经系统紊乱后，我们立即停止了IFN-α治疗。类固醇冲击疗法有效地缓解了患者的神经症状。据我们所知，这是首例IFN-α治疗肾细胞癌导致中枢和周围神经系统均出现副作用的病例。
