Nonoyama Masato, Kume Hikaru, Kumagai Ken, Souma Kazui, Sunakawa Keisuke
Department of Infectious Diseases, Kitasato University School of Medicine.
Kansenshogaku Zasshi. 2003 Nov;77(11):982-5. doi: 10.11150/kansenshogakuzasshi1970.77.982.
We report a case of candidemia due to Candida krusei after subarachinoid hemorrhage. A 51 year-old male patient consulted us for high fever and increase of CRP 10 days post operation against subarachinoid hemorrhage. There was a temporary decrease in the CRP after administration of ceftazidime (CAZ) but it again when treatment with CAZ was stopped. Because of detected Candida sp. by blood culture, fluconazole was administered i.v. for 5 days, but C. krusei was positive during the treatment. Therefore, fluconazole was replaced with micafungin. The patient became better after the administration with micafungin for 14 days without side effect. Micafungin is effective against candidemia due to C. krusei.
我们报告1例蛛网膜下腔出血后克鲁斯念珠菌引起的念珠菌血症病例。一名51岁男性患者在蛛网膜下腔出血手术后10天因高热和CRP升高前来就诊。给予头孢他啶（CAZ）后CRP暂时下降，但停用CAZ治疗后又再次升高。由于血培养检测到念珠菌属，静脉注射氟康唑5天，但治疗期间克鲁斯念珠菌呈阳性。因此，将氟康唑换为米卡芬净。患者在给予米卡芬净治疗14天后病情好转，且无副作用。米卡芬净对克鲁斯念珠菌引起的念珠菌血症有效。
