抗抑郁药或兴奋剂会导致儿童双相情感障碍更早发病？一种假说。
Earlier onset of bipolar disorder in children by antidepressants or stimulants? An hypothesis.
作者信息
Reichart Catrien G, Nolen Willem A
机构信息
Department of Child and Adolescent Psychiatry, Sophia Children's Hospital/Erasmus University of Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands.
出版信息
J Affect Disord. 2004 Jan;78(1):81-4. doi: 10.1016/s0165-0327(02)00180-5.
Among adults and adolescents, bipolar disorder (BD) has a similar prevalence in the US and in the Netherlands. However, among pre-pubertal children, BD is frequently diagnosed in the US and seldomly in the Netherlands. This suggests that, among children, the prevalence of BD is lower in the Netherlands than in the US, indicating an earlier onset of BD in the US than in the Netherlands. It is hypothesized that this may be related to the greater use of antidepressants and stimulants for depression or attention deficit disorder with hyperactivity by US children. In those children who are genetically at risk to develop BD, these drugs may lead to a switch into mania.
在成年人和青少年中，双相情感障碍（BD）在美国和荷兰的患病率相似。然而，在青春期前儿童中，BD在美国经常被诊断出来，而在荷兰则很少被诊断出来。这表明，在儿童中，BD在荷兰的患病率低于美国，这表明BD在美国比在荷兰发病更早。据推测，这可能与美国儿童更多地使用抗抑郁药和兴奋剂治疗抑郁症或注意力缺陷多动障碍有关。在那些有患BD遗传风险的儿童中，这些药物可能会导致转变为躁狂症。
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