Harland C C, Whitaker R P, Barron J L, Holden C A
Department of Dermatology, St Helier Hospital, Carshalton, U.K.
Br J Dermatol. 1992 Nov;127(5):453-7. doi: 10.1111/j.1365-2133.1992.tb14839.x.
The production of neopterin closely reflects activation of T-lymphocyte-mediated immunity. Oxidized and reduced forms of urine neopterin were measured by reversed-phase ion-pair high-performance liquid chromatography in patients with moderate to severe chronic plaque psoriasis (n = 40), and in a heterogeneous group of patients (n = 14) with cutaneous T-cell malignancies (CTCM). Results were compared with healthy non-psoriatic control subjects (n = 30). Neopterin levels were repeated after a course of ultraviolet B therapy (UVB) plus topical tar or dithranol, or photochemotherapy (PUVA), in 12 psoriatic patients. Fully oxidized urine neopterin levels and neopterin/creatinine ratios were significantly elevated in the psoriatic group compared with controls (P < 0.002, P < 0.05) but not in the CTCM group. Both neopterin and its creatinine ratio were significantly reduced by treatment (P < 0.05, P < 0.01). Psoriasis area and severity index scores (PASI) correlated strongly with urine neopterin levels (P < 0.001). These findings indicate that urine neopterin concentrations may be a marker of psoriatic disease activity, and further support the importance of activated T lymphocytes in the pathogenesis of psoriasis.
新蝶呤的产生密切反映了T淋巴细胞介导的免疫激活情况。采用反相离子对高效液相色谱法测定了中度至重度慢性斑块状银屑病患者（n = 40）以及一组异质性皮肤T细胞恶性肿瘤（CTCM）患者（n = 14）尿液中氧化型和还原型新蝶呤的含量。将结果与健康的非银屑病对照受试者（n = 30）进行比较。对12例银屑病患者进行了一个疗程的紫外线B疗法（UVB）加外用焦油或地蒽酚，或光化学疗法（PUVA）后，再次测定新蝶呤水平。与对照组相比，银屑病组完全氧化型尿液新蝶呤水平和新蝶呤/肌酐比值显著升高（P < 0.002，P < 0.05），但CTCM组未升高。治疗后新蝶呤及其肌酐比值均显著降低（P < 0.05，P < 0.01）。银屑病面积和严重程度指数评分（PASI）与尿液新蝶呤水平密切相关（P < 0.001）。这些发现表明，尿液新蝶呤浓度可能是银屑病疾病活动的一个标志物，并进一步支持了活化T淋巴细胞在银屑病发病机制中的重要性。
