日本甲状腺功能减退、肥胖及健康犬血清中通过酶联免疫吸附测定法检测到的甲状腺球蛋白自身抗体患病率。

Prevalence of thyroglobulin autoantibodies detected by enzyme-linked immunosorbent assay of canine serum in hypothyroid, obese and healthy dogs in Japan.

作者信息

Lee J Y, Uzuka Y, Tanabe S, Sarashina T

机构信息

Department of Veterinary Clinical Science, The United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, 501-1193, Gifu, Japan.

出版信息

Res Vet Sci. 2004 Apr;76(2):129-32. doi: 10.1016/j.rvsc.2003.10.002.

DOI:10.1016/j.rvsc.2003.10.002

PMID:14672855

Abstract

Thyroglobulin autoantibodies (TgAA) were detected in sera of hypothyroid (n=19), obese (n=28) and clinically healthy dogs (n=52) using a commercially available immunoassay kit. TgAA-positive results occurred in 10 of 19 hypothyroid, 1 of 28 obese and 1 of 52 clinically healthy dogs. The clinically healthy TgAA-positive dog had additional evidence of hypothyroidism supported by low total T(4), low free T(4) and high canine TSH. Among the breeds, Golden Retriever had the highest frequency of hypothyroid (9/19) and TgAA-positive hypothyroid dogs (6/10). This study was the first survey about the prevalence of canine TgAA in Japan and could be a useful reference for clinicians.

摘要

使用市售免疫分析试剂盒，在甲状腺功能减退犬（n = 19）、肥胖犬（n = 28）和临床健康犬（n = 52）的血清中检测甲状腺球蛋白自身抗体（TgAA）。19只甲状腺功能减退犬中有10只、28只肥胖犬中有1只、52只临床健康犬中有1只出现TgAA阳性结果。临床健康的TgAA阳性犬有甲状腺功能减退的其他证据，表现为总T4降低、游离T4降低和犬促甲状腺激素升高。在这些品种中，金毛寻回犬的甲状腺功能减退犬（9/19）和TgAA阳性甲状腺功能减退犬（6/10）的频率最高。本研究是日本关于犬TgAA患病率的首次调查，可为临床医生提供有用的参考。