Harland C C, Whittaker S J, Ng Y L, Holden C A, Wong E, Smith N P
Department of Dermatology, St Helier Hospital, Carshalton, U.K.
Br J Dermatol. 1992 Nov;127(5):519-23. doi: 10.1111/j.1365-2133.1992.tb14852.x.
Three patients with cutaneous T-cell lymphoma (CTCL) are reported who had concurrent B-cell chronic lymphocytic leukaemia (B-CLL). The separate lineage and clonal nature of the individual lymphoid malignancies were confirmed by gene-rearrangement analysis. The chronology of the illnesses did not support the hypothesis that CTCL predisposes to the development of B-cell proliferative disorders. There was no clear association with immunosuppressive therapy, and HTLV-1 studies were negative in all patients. Consequently, we speculate that a lymphoid stem cell defect, which may lead to the development of either aberrant B- or T-cell clones, may be responsible for such cases of dual lymphoid neoplasia.
报告了3例皮肤T细胞淋巴瘤（CTCL）患者，他们同时患有B细胞慢性淋巴细胞白血病（B-CLL）。通过基因重排分析证实了各淋巴恶性肿瘤的不同谱系和克隆性质。疾病的先后顺序不支持CTCL易引发B细胞增殖性疾病这一假说。与免疫抑制治疗无明显关联，且所有患者的人类T淋巴细胞病毒1型（HTLV-1）研究均为阴性。因此，我们推测，可能导致异常B细胞或T细胞克隆形成的淋巴干细胞缺陷，可能是此类双淋巴系统肿瘤病例的病因。
