Abril Andy, Cohen Marc D
Division of Rheumatology, Mayo Clinic, Jacksonville, Florida 32224, USA.
Curr Opin Rheumatol. 2004 Jan;16(1):51-5. doi: 10.1097/00002281-200401000-00010.
This review emphasizes the importance of the rheumatological signs and symptoms in the presentation of sarcoidosis. Often the presence of musculoskeletal findings may lead to the diagnosis of the disease and the institution of the appropriate treatment.
There have been significant advances in the treatment of sarcoidosis with the use of biologic agents for recalcitrant and severe manifestations of the disease as well as some new data regarding pathogenetics and new applications of diagnostic imaging studies such as positron emission tomography scanning.
Although pulmonary disease is the most frequent manifestation of sarcoidosis, musculoskeletal symptoms are not only common, but may be the initial presentation of this systemic inflammatory process and could mimic other arthritic and autoimmune disorders. This article focuses on the rheumatological aspects of sarcoidosis and includes a review of the most recent literature, which shows new data on the diagnosis, pathogenesis, and treatment of this condition.
本综述强调结节病临床表现中风湿病学体征和症状的重要性。肌肉骨骼方面的表现常常可引导疾病的诊断及恰当治疗的开展。
在结节病治疗方面取得了重大进展，生物制剂用于治疗该疾病的顽固性和严重表现，同时在发病机制方面有了一些新数据，正电子发射断层扫描等诊断性影像学研究也有了新应用。
尽管肺部疾病是结节病最常见的表现，但肌肉骨骼症状不仅常见，而且可能是这种全身性炎症过程的初始表现，还可能与其他关节炎和自身免疫性疾病相似。本文聚焦于结节病的风湿病学方面，并对最新文献进行了综述，这些文献展示了关于该疾病诊断、发病机制和治疗的新数据。
