Rusakov V V, Dolgikh V T
Biokhimiia. 1992 Sep;57(9):1393-7.
Studies on inbred male rats revealed that ischemia associated with clinical death caused by haemorrhage with subsequent recirculation and reoxygenation during resuscitation led to an increase in enzyme activities in blood serum and perfusate passed through the coronary bed of isolated hearts, presumably due to impaired membrane integrity. Damage to cardiomyocyte membranes was caused by intensification of LPO concomitant with enhanced glycolysis and lactate accumulation in the cardiac muscle. Carnosine (25 mg/kg) injected simultaneously with recirculation and reoxygenation prevented membrane damage and created optimal conditions for the functioning of membrane enzymes.
对近交系雄性大鼠的研究表明，出血导致临床死亡相关的缺血，以及复苏过程中随后的再灌注和再氧合，会导致血清和通过离体心脏冠状动脉床的灌注液中酶活性增加，这可能是由于膜完整性受损所致。心肌细胞膜的损伤是由脂质过氧化增强伴心肌中糖酵解增强和乳酸积累引起的。在再灌注和再氧合同时注射肌肽（25毫克/千克）可防止膜损伤，并为膜酶的功能发挥创造最佳条件。
