Mukhtar A U, Kagame K
Department of Pathology, Faculty of Medicine, Mbarara University of Science and Technology, P O Box 1410, Uganda.
Cent Afr J Med. 2000 Jan;46(1):13-6. doi: 10.4314/cajm.v46i1.8516.
Histological study of retinoblastoma: cellular differentiation, optic nerve and choroidal involvement.
Series of specimens examined in the Pathology laboratory.
Department of Pathology, Mbarara University Teaching Hospital (MUTH) and Ruharo Eye Centre, Mbarara.
32 eye specimens.
31 specimens consisted of poorly differentiated tumours and one specimen had a well differentiated retinoblastoma showing Flexner-Wintersteiner rosettes. Fifteen out of 25 specimens with optic nerves showed both choroid and optic nerve invasion. In 10 eye specimens, the optic nerves and choroid were free of tumour. In the remaining seven specimens, the optic nerves were not submitted with the enucleated specimens and there was no choroidal involvement on histology.
This review supports findings from previous studies done in Africa which indicated that poorly differentiated retinoblastoma is more common among African children than well differentiated retinoblastoma.
视网膜母细胞瘤的组织学研究：细胞分化、视神经及脉络膜受累情况。
在病理实验室检查的一系列标本。
姆巴拉拉大学教学医院（MUTH）病理科及姆巴拉拉鲁哈罗眼科中心。
32份眼标本。
31份标本为低分化肿瘤，1份标本为高分化视网膜母细胞瘤，可见弗莱克斯纳-温特施泰纳菊形团。25份带有视神经的标本中，15份显示脉络膜和视神经均受侵犯。10份眼标本中，视神经和脉络膜无肿瘤。其余7份标本中，摘除的标本未包含视神经，组织学检查显示无脉络膜受累。
本综述支持此前在非洲开展的研究结果，即低分化视网膜母细胞瘤在非洲儿童中比高分化视网膜母细胞瘤更常见。
