Philipson L, Pettersson R F
Department of Cell and Molecular Biology, Karolinska Institute, Box 285, 17177 Stockholm, Sweden.
Curr Top Microbiol Immunol. 2004;273:87-111. doi: 10.1007/978-3-662-05599-1_3.
The physiological and cell biological aspects of the Coxsackie-Adenovirus Receptor (CAR) is discussed in this review. The receptor obviously recognizes the group C adenoviruses in vivo, but also fibers from other groups except group B in vitro. The latter viruses seem to utilize a different receptor. The receptor accumulates at, or close to, the tight junction in polarized epithelial cells and probably functions as a cell-cell adhesion molecule. The cytoplasmic tail of the receptor is not required for virus attachment and uptake. Although there is a correlation between CAR and uptake of adenoviruses in several human tumor cells, evidence of an absolute requirement for integrins has not been forthcoming. The implication of these findings for adenovirus gene therapy is discussed.
本综述讨论了柯萨奇病毒-腺病毒受体（CAR）的生理和细胞生物学方面。该受体在体内明显识别C组腺病毒，但在体外也能识别除B组以外其他组的纤维。后一类病毒似乎利用不同的受体。该受体在极化上皮细胞的紧密连接处或其附近积聚，可能作为一种细胞间粘附分子发挥作用。病毒附着和摄取不需要该受体的胞质尾。虽然在几种人类肿瘤细胞中，CAR与腺病毒摄取之间存在相关性，但尚未有证据表明整合素是绝对必需的。本文还讨论了这些发现对腺病毒基因治疗的意义。
