Swaak A J, Nossent J C, Smeenk R J
Department of Rheumatology, Dr. Daniel den Hoed Clinic, Rotterdam, The Netherlands.
Int J Clin Lab Res. 1992;22(4):190-5. doi: 10.1007/BF02591422.
The reported change in the incidence of systemic lupus erythematosus (SLE) is mainly due to a greater awareness of the disease, and to the introduction of serological detection methods such as the LE cell assay and subsequently a variety of other antinuclear antibody assays. SLE is seldom preceded by rheumatoid arthritis, nor does SLE often develop in patients with rheumatoid arthritis. In a substantial proportion of our SLE patients, discoid LE occurred first. On analyzing the literature no evidence could be found that nowadays less severe SLE is diagnosed. Also, in the last three decades no change has been observed in the prevalence of clinical features in large groups of patients with SLE. These data indicate that there has been no change in the expression or prognosis of SLE in recent decades.
系统性红斑狼疮（SLE）发病率的报道变化主要归因于对该疾病的认识提高，以及血清学检测方法的引入，如LE细胞检测，随后还有各种其他抗核抗体检测。SLE很少先于类风湿性关节炎出现，类风湿性关节炎患者也不常发展为SLE。在我们的大部分SLE患者中，盘状红斑狼疮首先出现。分析文献发现，目前没有证据表明诊断出的SLE病情较轻。此外，在过去三十年中，大量SLE患者的临床特征患病率没有变化。这些数据表明，近几十年来SLE的表现或预后没有变化。
