系统性红斑狼疮患者盘状红斑狼疮的发病率评估及其与疾病活动度的关系。

Evaluation of the incidence of discoid lupus erythematosus in patients with systemic lupus erythematosus and its relationship to disease activity.

作者信息

Saghafi Massoud, Hashemzadeh Kamila, Sedighi Sima, Yazdanpanah Mohammad Javad, Rezaieyazdi Zahra, Sahebari Maryam, Esmaily Habibollah

出版信息

J Cutan Med Surg. 2014 Oct;18(5):316-9. doi: 10.2310/7750.2014.13122.

DOI:10.2310/7750.2014.13122

PMID:25186992

Abstract

BACKGROUND

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with wide clinical features ranging from cutaneous manifestations to systemic disease. Skin is one of the most commonly affected organs in SLE.

OBJECTIVE

To determine whether there is any correlation between discoid lupus erythematosus (DLE) and the severity of SLE.

METHODS

In a prospective cross-sectional study, 60 consecutive patients with newly diagnosed SLE were enrolled. Skin biopsy was performed to establish the diagnosis of DLE. Disease activity was determined by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). A SLEDAI-2K score ≥ 10 was considered active and severe disease.

RESULTS

Eleven SLE patients (9 females and 2 males) had DLE (18.3%) and 49 patients (46 females and 3 males) had SLE without DLE (81.7%). The mean age of patients with DLE was 30.18 ± 11.07 years and in patients without it was 28.4 ± 10.26 years (p = .6). Three of 11 patients with DLE (27.3%) and 14 of 49 patients without DLE (28.6%) had a SLEDAI-2K score ≥ 10 (p = 1).

CONCLUSION

The presence of DLE in our patients with SLE was not associated with less severe disease.

摘要

背景

系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，临床特征广泛，从皮肤表现到全身性疾病。皮肤是SLE中最常受累的器官之一。

目的

确定盘状红斑狼疮（DLE）与SLE严重程度之间是否存在相关性。

方法

在一项前瞻性横断面研究中，连续纳入60例新诊断的SLE患者。进行皮肤活检以确诊DLE。采用系统性红斑狼疮疾病活动指数2000（SLEDAI-2K）确定疾病活动度。SLEDAI-2K评分≥10被认为是疾病活动且严重。

结果

11例SLE患者（9例女性和2例男性）患有DLE（18.3%），49例患者（46例女性和3例男性）患有无DLE的SLE（81.7%）。患有DLE的患者平均年龄为30.18±11.07岁，无DLE的患者平均年龄为28.4±10.26岁（p = 0.6）。11例患有DLE的患者中有3例（27.3%）和49例无DLE的患者中有14例（28.6%）的SLEDAI-2K评分≥10（p = 1）。