Eymard B, Hauw J J
Service de Neurologie, Hôpital de la Salpêtrière, Paris, France.
Curr Opin Neurol Neurosurg. 1992 Dec;5(6):909-16.
Molecular genetic studies are now bringing a new classification and new insights into already recognized mitochondrial encephalomyopathies. There are, however, numerous reports on an overlap pattern between mitochondriopathies. In addition, the link between the defect in oxidative phosphorylation (OXPHOS) in the brain and the specific neuropathological pattern is unclear. A better knowledge of nuclear mutations in mitochondriopathies and of the interactions between nuclear and mitochondrial genomes will probably allow new developments.
分子遗传学研究正在为已被认可的线粒体脑肌病带来新的分类和新的见解。然而，关于线粒体病之间重叠模式的报道众多。此外，大脑中氧化磷酸化（OXPHOS）缺陷与特定神经病理模式之间的联系尚不清楚。更好地了解线粒体病中的核突变以及核基因组与线粒体基因组之间的相互作用可能会带来新的进展。
