Budka H
Neurological Institute, University of Vienna, Austria.
Curr Opin Neurol Neurosurg. 1992 Dec;5(6):917-23.
Complementary to a clinical classification of human immunodeficiency virus (HIV)-associated nervous system syndromes, a neuropathology-based terminology defines entities at tissue level, including the new HIV-specific diseases, HIV encephalitis and HIV leukoencephalopathy. Poor clinico-neuropathological correlation may be explained by complex pathogenetic mechanisms in which several factors, including virus load, neurotoxicity, vascular changes, and metabolic abnormalities, may act together to damage both white and gray matter of the brain.
作为人类免疫缺陷病毒（HIV）相关神经系统综合征临床分类的补充，基于神经病理学的术语在组织水平定义了一些实体，包括新的HIV特异性疾病、HIV脑炎和HIV白质脑病。临床与神经病理学之间的相关性较差，这可能是由复杂的发病机制所解释的，在这些机制中，包括病毒载量、神经毒性、血管变化和代谢异常在内的多种因素可能共同作用，损害大脑的白质和灰质。
