Nagaoka Shunji, Bito Yukiko, Sakuma Rie, Nomura Hiroko, Hata Tadayoshi, Nishiyama Junpei, Hirata Yutaka
Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.
Biol Sci Space. 2003 Oct;17(3):265-6.
We analyzed and compared the frequency components of the heart rate variability in human neonate, rat, white chicken, turtle, and frog during the developments. Frequency analysis with autocorrelation-FFT method was applied to the heart rate and respiration waves to calculate the respiration induced frequency component in the power spectra. The comparative analysis of the cardiopulmonary reflex in human and rat neonates resulted in a similar developmental progress. In case of human immature neonate, respiration induced frequency component in the heart rate variability was negligible at day-old 0, and significantly increased at postnatal 1 month. The rat neonates also showed no or negligible respiration induced components until days 8 and it became significant approximately postnatal 1 month. The white chicken also indicated negligible respiration induced component before and a few days after hatching, and became significant after 38 days-old (17 days post hatching). However the frog and the turtle indicated no clear response in entire periods of the development even in adult. The results strongly suggested that gravity may be a possible essential factor of the appearance of the post natal development of the cardiopulmonary reflex.
我们分析并比较了人类新生儿、大鼠、白鸡、乌龟和青蛙在发育过程中心率变异性的频率成分。采用自相关-快速傅里叶变换（autocorrelation-FFT）方法对心率和呼吸波进行频率分析，以计算功率谱中呼吸诱导的频率成分。对人类和大鼠新生儿心肺反射的比较分析得出了相似的发育进程。对于人类未成熟新生儿，心率变异性中呼吸诱导的频率成分在出生0天时可忽略不计，在出生后1个月时显著增加。大鼠新生儿在出生8天之前也未显示或仅有可忽略不计的呼吸诱导成分，在出生后约1个月时变得显著。白鸡在孵化前和孵化后几天也显示出可忽略不计的呼吸诱导成分，在38日龄（孵化后17天）后变得显著。然而，青蛙和乌龟在整个发育阶段甚至成年期都没有明显反应。结果强烈表明，重力可能是心肺反射出生后发育出现的一个可能的关键因素。
