Mohr Alicia M, Lavery Robert F, Barone Allison, Bahramipour Philip, Magnotti Louis J, Osband Adena J, Sifri Ziad, Livingston David H
Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medcial School, Newark, 07103, USA.
J Trauma. 2003 Dec;55(6):1077-81; discussion 1081-2. doi: 10.1097/01.TA.0000100219.02085.AB.
Angiographic embolization (AE) is a safe and effective method for controlling hemorrhage in both blunt and penetrating liver injuries. Improved survival after hepatic injuries has been documented using a multimodality approach; however, patients still have significant long-term morbidity. This study examines further the role of AE in both blunt and penetrating liver injuries and the outcomes of its use.
The medical records of 37 consecutive patients admitted from 1995 to 2002 to a Level I trauma center who underwent hepatic angiography with the intent to embolize were reviewed. Demographic and clinical information including Injury Severity Score, length of stay, mortality, intra-abdominal complications, admission physiologic variables, and the number and type of abdominal operations performed were collected.
Thirty-seven patients underwent hepatic angiography and 26 patients had hepatic embolization performed. Eleven patients underwent early-AE, immediately after computed tomographic scanning, and 15 underwent late-AE, after liver-related operations or later in their hospital course. There was a 27% mortality rate overall. There were 11 liver-related complications in the 26 embolizations. Excluding the early deaths, the associated morbidity was 58%, which included hepatic necrosis, hepatic abscesses, and bile leaks.
There is increasing adjunctive use of AE in patients managed both operatively and nonoperatively. Intra-abdominal complications are common in these salvaged patients with severe liver injuries. Those patients that underwent early-AE received significantly fewer blood transfusions and more commonly had sterile hepatic collections. Only 26% of patients required liver-related surgery after AE. Therefore, the integration of AE as an adjunctive modality for patients with high-grade liver injuries is a safe and effective therapeutic option.
血管造影栓塞术(AE)是控制钝性和穿透性肝损伤出血的一种安全有效的方法。采用多模式方法已证明肝损伤后生存率有所提高;然而,患者仍有显著的长期发病率。本研究进一步探讨AE在钝性和穿透性肝损伤中的作用及其使用结果。
回顾了1995年至2002年期间连续入住一级创伤中心且接受肝血管造影以进行栓塞的37例患者的病历。收集了人口统计学和临床信息,包括损伤严重程度评分、住院时间、死亡率、腹腔内并发症、入院时的生理变量以及腹部手术的数量和类型。
37例患者接受了肝血管造影,26例患者进行了肝栓塞。11例患者在计算机断层扫描后立即接受早期AE,15例在肝脏相关手术之后或住院过程后期接受晚期AE。总体死亡率为27%。26次栓塞中有11例发生肝脏相关并发症。排除早期死亡病例,相关发病率为58%,包括肝坏死、肝脓肿和胆漏。
在接受手术和非手术治疗的患者中,AE的辅助使用越来越多。在这些严重肝损伤的获救患者中,腹腔内并发症很常见。接受早期AE的患者输血次数明显减少,无菌性肝积液更为常见。AE后仅26%的患者需要进行肝脏相关手术。因此,将AE作为高级别肝损伤患者的辅助治疗手段是一种安全有效的治疗选择。