Hayes R B, de Jong F H, Raatgever J, Bogdanovicz J, Schroeder F H, van der Maas P, Oishi K, Yoshida O
Department of Urology, Erasmus University Rotterdam, The Netherlands.
Eur J Cancer Prev. 1992 Apr;1(3):239-45. doi: 10.1097/00008469-199204000-00005.
A case-control study of prostatic cancer was carried out to examine the association between selected physical characteristics and factors related to sexual development and behaviour and the risk for this disease. In consideration of an endocrinologic mechanism for these putative risk factors, the association between selected factors and serum hormone level in a comparison group, free of prostate cancer, was also examined. One-hundred cases and 113 controls were included for study. An elevated risk for prostatic cancer was found for those currently married (odds ratio (OR) = 4.0), those who had been married once (OR = 2.8), and those who were currently practising a religion (OR = 2.0). Compared to subjects with one child, those with more than one child and those with no children were more common among cases than controls. Prostatic cancer risk was associated with large body size and, in particular, with greater weight (p < 0.01). Early age at attainment of adult height was also associated with prostatic cancer risk (p < 0.01). Only moderate associations were found between increased frequency of sexual intercourse and prostatic cancer risk. The levels of testosterone (T), dihydrotestosterone, salivary testosterone and T/SHBG (sex hormone binding globulin) did not vary with age. Older men had higher oestradiol levels. Further, little association between hormone levels and risk factors was found, except for married subjects having increased serum androgens (p < 0.05) and heavy subjects having decreased serum androgens (not significant).
开展了一项前列腺癌病例对照研究，以检验选定的身体特征、与性发育和行为相关的因素与该疾病风险之间的关联。考虑到这些假定风险因素的内分泌学机制，还研究了一组无前列腺癌的对照组中选定因素与血清激素水平之间的关联。共纳入100例病例和113例对照进行研究。发现当前已婚者（比值比（OR）=4.0）、曾结过一次婚者（OR = 2.8）以及当前信奉宗教者（OR = 2.0）患前列腺癌的风险升高。与育有一个孩子的受试者相比，育有多个孩子和没有孩子的受试者在病例中比在对照中更为常见。前列腺癌风险与体型较大有关，尤其是与体重较重有关（p<0.01）。成年身高达成时年龄较早也与前列腺癌风险有关（p<0.01）。性交频率增加与前列腺癌风险之间仅发现中度关联。睾酮（T）、双氢睾酮、唾液睾酮和T/SHBG（性激素结合球蛋白）水平不随年龄变化。老年男性的雌二醇水平较高。此外，除已婚受试者血清雄激素增加（p<0.05）和体重较重者血清雄激素降低（不显著）外，未发现激素水平与风险因素之间有明显关联。
