Avivi S, Nitzan Y, Dror R, Gedanken A
Department of Chemistry, Bar-Ilan University, Ramat-Gan, 52900 Israel.
J Am Chem Soc. 2003 Dec 24;125(51):15712-3. doi: 10.1021/ja036834+.
A one-step sonochemical process starting with the native BSA and tetracycline was employed to encapsulate the antibiotic drug in microspheres of BSA. The tetracycline loading studies showed that the maximum tetracycline loading capacity was found to be 65%. The antimicrobial activity of the tetracycline loaded in BSA microspheres was demonstrated on two bacterial strains that are sensitive to tetracycline.
采用一种从天然牛血清白蛋白（BSA）和四环素开始的一步声化学过程，将抗生素药物包裹在BSA微球中。四环素负载研究表明，最大四环素负载量为65%。对两种对四环素敏感的细菌菌株展示了负载在BSA微球中的四环素的抗菌活性。
