Dias Pereira Patrícia, Faustino Augusto M R
ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Largo Prof Abel Salazar, Porto 4099-003, Portugal.
Vet Dermatol. 2003 Dec;14(6):333-7. doi: 10.1111/j.1365-3164.2003.00350.x.
Eight cases of feline plasma cell pododermatitis, collected over a 3-year period, were studied using histological (haematoxylin and eosin), histochemical (methyl green-pyronin) and immunohistochemical (antibody against lambda light chains of immunoglobulins) techniques. No sex, breed or age predisposition, or paw predilection was observed. The disease began as a swelling of the footpads, followed by ulceration. Histologically, lesions were characterized by the presence of a large number of plasma cells in a predominantly perivascular pattern. Binucleated plasma cells and mitotic figures were observed. Clinical follow-up for over 1 year revealed total remission of the lesions both after glucocorticoid therapy in four cases, and total surgical excision in two animals. Follow-up studies were not possible in one case.
在3年时间里收集了8例猫浆细胞性足皮炎病例，采用组织学（苏木精和伊红染色）、组织化学（甲基绿-派洛宁染色）和免疫组织化学（抗免疫球蛋白λ轻链抗体）技术进行研究。未观察到性别、品种、年龄倾向或爪部偏好。疾病开始时表现为脚垫肿胀，随后出现溃疡。组织学上，病变的特征是大量浆细胞主要呈血管周围分布。观察到双核浆细胞和有丝分裂象。对4例进行糖皮质激素治疗以及对2只动物进行手术全切后的临床随访超过1年，结果显示病变完全缓解。1例无法进行随访研究。
