沿着一条通往基因不稳定的不同途径发展。
Tumbling down a different pathway to genetic instability.
作者信息
Guo Haiwei H, Loeb Lawrence A
机构信息
Jospeh Gottstein Research Laboratory, Department of Pathology, University of Washington, Seattle 98195-7705, USA.
出版信息
J Clin Invest. 2003 Dec;112(12):1793-5. doi: 10.1172/JCI20502.
Abstract
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
摘要
溃疡性结肠炎（UC）是一种与结肠癌易感性相关的慢性炎症性疾病，其特征通常是微卫星不稳定性（MSI）形式的DNA损伤。一项新报告将UC中的炎症与DNA修复酶3-甲基腺嘌呤DNA糖基化酶和脱嘌呤/脱嘧啶内切核酸酶的增加联系起来，并且矛盾的是，还与MSI增加有关。这些发现可能代表了一种导致慢性炎症中MSI的新机制。
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