[Problems in the management of HIV infection in clinical practice. Patients still on dual therapy 8 years after the introduction of HAART].

Eight years after the introduction of HAART as the standard therapy of HIV disease, around one fifth of treated patients of our cohort still rely on isolated dual nucleoside analogue administration, mostly due to an apparently effective treatment initiated with these last drugs before the HAART era, or severe intolerance to triple regimens based on protease inhibitors or non-nucleoside reverse transcriptase inhibitors, or patient's refusal of HAART. Three representative case reports are described, and their implications discussed on the ground of current guidelines of antiretroviral therapy and common clinical practice.