Khodair Ahmed I, Al-Masoudi Najim A, Gesson Jean-Pierre
Chemistry Department, Faculty of Education, Tanta University (Kafr El-Sheikh Branch), Kafr El-Sheikh, Egypt.
Nucleosides Nucleotides Nucleic Acids. 2003 Nov;22(11):2061-76. doi: 10.1081/NCN-120026407.
A modified nitrogen and sulfur glycosylation reaction involving benzothiazole benzoxazole and pyridine nucleoside bases with furanose and pyranose sugars are described. Conformational analysis has been studied by homo- and heteronuclear two-dimensional NMR methods (2D DFQ-COSY, HMQC and HMBC). The N and S sites of glycosylation were determined from the 1H, 13C heteronuclear multiple-quantum coherence (HMQC) experiments. All the deprotected nucleosides were tested for their potential antitumor activity.
描述了一种涉及苯并噻唑、苯并恶唑和吡啶核苷碱基与呋喃糖和吡喃糖的改良氮和硫糖基化反应。通过同核和异核二维核磁共振方法（二维双频量子化学相关谱、异核多量子相干谱和异核多键相关谱）研究了构象分析。从氢-碳异核多量子相干谱实验中确定了糖基化的氮和硫位点。对所有脱保护的核苷进行了潜在抗肿瘤活性测试。
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