新型 2',3'-二乙硫基-2',3',5'-三脱氧-5'-三唑核苷类似物的合成及抗肿瘤活性。
Synthesis and antitumor activity of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside analogues.
机构信息
Department of Applied Chemistry and Pharmacy, Beijing Institute of Technology, Nandajie 5, Beijing 100081, P.R. China.
出版信息
Eur J Med Chem. 2010 Jul;45(7):3219-22. doi: 10.1016/j.ejmech.2010.03.038. Epub 2010 Apr 3.
PMID:20409617
Abstract
A series of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.
摘要
一系列新型 2',3'-二乙硫基-2',3',5'-三脱氧-5'-三氮唑核苷被以优异的产率合成，并对其抗肿瘤活性进行了评估。这些带有芳香取代三唑环的核苷类似物对广泛的肿瘤细胞系表现出显著改善的活性，而没有芳基取代的则没有活性。
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