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JASPAR：一个用于真核转录因子结合图谱的开放获取数据库。

JASPAR: an open-access database for eukaryotic transcription factor binding profiles.

作者信息

Sandelin Albin, Alkema Wynand, Engström Pär, Wasserman Wyeth W, Lenhard Boris

机构信息

Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, S-17177 Stockholm, Sweden.

出版信息

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D91-4. doi: 10.1093/nar/gkh012.

DOI:10.1093/nar/gkh012
PMID:14681366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308747/
Abstract

The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genome-wide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.

摘要

基因组序列调控区域的分析很大程度上基于潜在转录因子结合位点的检测。用于表示转录因子结合特异性的首选模型被称为位置特异性评分矩阵。JASPAR是一个开放获取的数据库，包含多细胞真核生物经过注释的、高质量的、基于矩阵的转录因子结合位点图谱。这些图谱完全来自经实验证明能结合转录因子的核苷酸序列集。该数据库辅以用于浏览、搜索和子集选择的网络界面、在线序列分析工具以及用于调控区域全基因组和比较基因组分析的一套编程工具。可通过http://jaspar.cgb.ki.se访问JASPAR。

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