Ivanova V, Karaivanov M, Marinov E, Gorchev G, Velkova A, Khristova P
Akush Ginekol (Sofiia). 2003;42(5):3-8.
The objectives of this study were to: 1) characterize histologically endometrial biopsy findings for genital bleeding in breast cancer patients receiving Tamoxifen; 2) analyze histologically endometrial carcinoma in the same patients. We analyzed biopsy specimens divided into three groups: 1) 112 biopsies (curettages and hysterectomy specimens) from 88 breast cancer patients receiving Tamoxifen (Nolvadex): T+; 2) 27 biopsies (curettages and hysterectomy specimens) from 22 breast cancer patients not receiving Tamoxifen but biopsied for genital bleeding: T-; 3) 139 curettages control samples received for analysis in the period January-March 2000 from women with peri- and postmenopausal genital bleeding: K. The analysis was performed on archival H&E sections. The most frequent finding in breast cancer patients receiving Tamoxifen was endometrial polyp. Compared with the other two groups (T- and K) the frequency of this finding was statistically significant. No difference was found in the prevalence of endometrial cancer between the three groups. The analyzed endometrial carcinomas in Tamoxifen-treated breast cancer patients show signs, characteristic of Bochman type I: predominantly endometrioid, of low grade and FIGO stage, with good prognosis.
1）从组织学上描述接受他莫昔芬治疗的乳腺癌患者生殖器出血的子宫内膜活检结果；2）对同一患者的子宫内膜癌进行组织学分析。我们分析了分为三组的活检标本：1）来自88例接受他莫昔芬（诺瓦得士）治疗的乳腺癌患者的112份活检标本（刮宫和子宫切除标本）：T+；2）来自22例未接受他莫昔芬但因生殖器出血而进行活检的乳腺癌患者的27份活检标本（刮宫和子宫切除标本）：T-；3）2000年1月至3月期间从有围绝经期和绝经后生殖器出血的女性中获取用于分析的139份刮宫对照样本：K。分析在存档的苏木精-伊红切片上进行。接受他莫昔芬治疗的乳腺癌患者中最常见的发现是子宫内膜息肉。与其他两组（T-和K）相比，这一发现的频率具有统计学意义。三组之间子宫内膜癌的患病率没有差异。在接受他莫昔芬治疗的乳腺癌患者中分析的子宫内膜癌显示出博克曼I型的特征：主要为子宫内膜样，低级别，FIGO分期，预后良好。
