Vladimirov Ia, Tacheva D, Blagoeva V
Medical University, Sofia.
Akush Ginekol (Sofiia). 2003;42(5):14-20.
To determine the predictive value of basal estradiol, FSH and inhibin B levels, antral follicle count and mean ovarian diameter of ovarian response in controlled ovarian hyperstimulation (COH), in outcome with normal FSH concentration in early follicular phase of menstrual cycle.
Twenty nine patients undergoing IVF treatment. Blood samples were collected and transvaginal ultrasound was performed on early follicular phase of unstimulated cycle. Controlled ovarian hyperstimulation (COH) was performed on the base of long protocol.
RESULT(S): Mean women age and basal FSH levels were significantly higher in cancelled cycles than in the control group, whereas basal inhibin B, mean ovarian diameter and antral follicle count was significantly higher in the latter. Mean basal E2 concentration was similar in both groups.
CONCLUSION(S): In women with normal basal FSH level the determination of E2 has no prognostic value of poor response outcome. However, inhibin B, antral follicles count and mean ovarian diameter tests when applied separately are with good prognostic values.
确定在月经周期卵泡早期促卵泡激素（FSH）浓度正常的情况下，基础雌二醇、FSH、抑制素B水平、窦卵泡计数及平均卵巢直径对控制性卵巢刺激（COH）中卵巢反应的预测价值，以及对治疗结果的影响。
选取29例行体外受精（IVF）治疗的患者。在未刺激周期的卵泡早期采集血样并进行经阴道超声检查。基于长方案进行控制性卵巢刺激（COH）。
取消周期组女性的平均年龄和基础FSH水平显著高于对照组，而对照组的基础抑制素B、平均卵巢直径和窦卵泡计数显著更高。两组的平均基础雌二醇浓度相似。
对于基础FSH水平正常的女性，测定雌二醇对预测不良反应结果无预后价值。然而，单独应用抑制素B、窦卵泡计数和平均卵巢直径检测具有良好的预后价值。
