Ivanov S, Zervoudis S, Ivanov S
Akush Ginekol (Sofiia). 2003;42(5):22-4.
In this research work we show our and foreign experience in preserving the ovarian function in young women and cervical cancer stage I B and II A. 6 cases are quoted for the period of time from 1987 till 2003 (4 patients with ovarian metastases from our experience and 2 patients with ovarian metastases found from the greek colleagues). Histologically 3 patients were with adenosquamous metastatic cervical cancers and 3 patients with squamous metastatic cervical cancers in the region of the transposed ovaries. The metastases occurred mostly 2 to 3 years after the radical hysterectomies a modo Wertheim-Meigs. Nevertheless our experience which is connected with radical hysterectomies a modeo W. Meigs including both ovaries, we have also experience in transposing ovaries /one or both of them/. In some of them we found metastases. In our research work we found 4 cases with metastases in transposed ovaries. In these cases a chemotherapy was applied: mitomicin C, etoposide, and cysplatinum. The greek colleagues also have applied such schemes of chemotherapy. 3 from the patients had a very good effect from the chemotherapy, in 2 the recurrences have appeared 2 years after the chemotherapy, and in one case there was a very big progression of the disease, nevertheless the chemotherapy. IT is very important for the oncogynaecologist to clear up if the transposition of the ovaries is safe and effective, especially in young patients with early cervical cancer receiving postoperative radiotherapy. That is why we did this research work in order to give more light on this problem.
在这项研究工作中,我们展示了我们自己以及国外在保留年轻女性和宫颈癌ⅠB期及ⅡA期患者卵巢功能方面的经验。引用了1987年至2003年期间的6个病例(根据我们的经验有4例卵巢转移患者,以及从希腊同事那里得知的2例卵巢转移患者)。组织学检查显示,3例患者为腺鳞转移性宫颈癌,3例患者为转移至移位卵巢区域的鳞状转移性宫颈癌。转移大多发生在根治性子宫切除术后(Wertheim-Meigs术式)2至3年。然而,我们在包括双侧卵巢的W. Meigs式根治性子宫切除术方面有经验,我们也有卵巢移位(一侧或双侧)的经验。在其中一些病例中我们发现了转移。在我们的研究工作中,我们发现4例移位卵巢中有转移。对于这些病例应用了化疗:丝裂霉素C、依托泊苷和顺铂。希腊同事也应用了这样的化疗方案。3例患者化疗效果非常好,2例在化疗后2年出现复发,1例尽管进行了化疗但疾病进展非常严重。对于肿瘤妇科医生来说,弄清楚卵巢移位是否安全有效非常重要,尤其是对于接受术后放疗的早期宫颈癌年轻患者。这就是我们开展这项研究工作的原因,以便更清楚地了解这个问题。