偶然分枝杆菌性角膜炎。动物模型中局部应用环丙沙星和阿米卡星的比较。

Mycobacterium fortuitum keratitis. A comparison of topical ciprofloxacin and amikacin in an animal model.

作者信息

Stevens R K, Holland G N, Paschal J F, Phinney R B, Berlin O G, Bruckner D A

机构信息

University of California, Jules Stein Eye Institute, Department of Ophthalmology, Los Angeles.

出版信息

Cornea. 1992 Nov;11(6):500-4.

PMID:1468211

Abstract

The effect of topical amikacin or topical ciprofloxacin on Mycobacterium fortuitum keratitis was studied in a rabbit model. Two strains of M fortuitum were used: ATCC-6841 [for which mean inhibitory concentrations (MICs) indicated in vitro sensitivity to both drugs] and a cutaneous isolate from a human infection (for which MICs indicated relative in vitro resistance to amikacin but in vitro sensitivity to ciprofloxacin). Both drugs reduced the number of organisms in eyes infected with either strain (all p values < or = 0.01), but in no cases were organisms eliminated from eyes after 4 days of treatment. Amikacin was more effective in reducing the number of organisms in corneas infected with ATCC-6841 than in corneas infected with the patient isolate (p = 0.004), whereas ciprofloxacin was equally effective for treatment of both strains (p > 0.10). These results suggest that topical amikacin or ciprofloxacin may be useful in the treatment of M fortuitum keratitis. However, neither drug was shown to be more effective for treatment of either strain studied (all p values > 0.3).

摘要

在兔模型中研究了局部应用阿米卡星或环丙沙星对偶然分枝杆菌性角膜炎的影响。使用了两株偶然分枝杆菌：ATCC - 6841（其平均抑制浓度表明对两种药物均有体外敏感性）和一株来自人类感染的皮肤分离株（其平均抑制浓度表明对阿米卡星有相对体外耐药性，但对环丙沙星有体外敏感性）。两种药物均减少了感染任一菌株的眼中的细菌数量（所有p值≤0.01），但在治疗4天后，没有任何一例眼中的细菌被清除。阿米卡星在减少感染ATCC - 6841的角膜中的细菌数量方面比感染患者分离株的角膜更有效（p = 0.004），而环丙沙星对两种菌株的治疗效果相同（p＞0.10）。这些结果表明局部应用阿米卡星或环丙沙星可能对偶然分枝杆菌性角膜炎的治疗有用。然而，对于所研究的任一菌株，均未显示出哪种药物更有效（所有p值＞0.3）。