Raychaudhuri Subhadip, Chakraborty Arup K, Kardar Mehran
Department of Chemical Engineering, University of California Berkeley, Berkeley, California 94720, USA.
Phys Rev Lett. 2003 Nov 14;91(20):208101. doi: 10.1103/PhysRevLett.91.208101. Epub 2003 Nov 10.
The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T cells and antigen presenting cells during recognition. The synapse is implicated in information transfer between cells, and is characterized by different spatial patterns of receptors at different stages in the life cycle of T cells. We obtain a minimalist model that captures this experimentally observed phenomenology. A functional renormalization group analysis provides further insights.
免疫突触是在识别过程中于T细胞和抗原呈递细胞之间的细胞间连接处形成的不同类型受体和配体的模式化集合。该突触与细胞间的信息传递有关,其特征在于T细胞生命周期不同阶段受体的不同空间模式。我们获得了一个捕捉这种实验观察到的现象学的极简模型。功能重整化群分析提供了进一步的见解。