Lee Kyeong-Hee, Dinner Aaron R, Tu Chun, Campi Gabriele, Raychaudhuri Subhadip, Varma Rajat, Sims Tasha N, Burack W Richard, Wu Hui, Wang Julia, Kanagawa Osami, Markiewicz Mary, Allen Paul M, Dustin Michael L, Chakraborty Arup K, Shaw Andrey S
Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA.
Science. 2003 Nov 14;302(5648):1218-22. doi: 10.1126/science.1086507. Epub 2003 Sep 25.
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
免疫突触是T细胞与抗原呈递细胞表面之间的一种特殊的细胞间连接。它的特征是抗原受体的中央簇、整合素家族黏附分子环以及数小时的时间稳定性。这种特定组织在T细胞激活信号传导中的作用一直存在争议。我们通过体外和计算机模拟实验确定，免疫突触充当一种自适应控制器，既能增强T细胞受体触发，又能减弱强信号。
