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可兴奋心脏组织中阻尼传播的时空动力学

Spatiotemporal dynamics of damped propagation in excitable cardiac tissue.

作者信息

Sidorov Veniamin Y, Aliev Rubin R, Woods Marcella C, Baudenbacher Franz, Baudenbacher Petra, Wikswo John P

机构信息

Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA.

出版信息

Phys Rev Lett. 2003 Nov 14;91(20):208104. doi: 10.1103/PhysRevLett.91.208104. Epub 2003 Nov 13.

Abstract

Compared to steadily propagating waves (SPW), damped waves (DW), another solution to the nonlinear wave equation, are seldom studied. In cardiac tissue after electrical stimulation in an SPW wake, we observe DW with diminished amplitude and velocity that either gradually decrease as the DW dies, or exhibit a sharp amplitude increase after a delay to become an SPW. The cardiac DW-SPW transition is a key link in understanding defibrillation and stimulation close to the refractory period, and is ideal for a general study of DW dynamics.

摘要

与持续传播波(SPW)相比,阻尼波(DW)作为非线性波动方程的另一种解,很少受到研究。在持续传播波尾迹中的电刺激后心脏组织中,我们观察到振幅和速度减小的阻尼波,其要么在阻尼波消失时逐渐减小,要么在延迟后振幅急剧增加而变成持续传播波。心脏阻尼波 - 持续传播波转变是理解除颤和接近不应期刺激的关键环节,并且是研究阻尼波动力学的理想对象。

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