多种黄酮类化合物及相关化合物的抗增殖活性：α-干扰素2b的相加作用

Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.

作者信息

Blank Viviana C, Poli Cecilia, Marder Mariel, Roguin Leonor P

机构信息

Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Junín 956, 1113 Buenos Aires, Argentina.

出版信息

Bioorg Med Chem Lett. 2004 Jan 5;14(1):133-6. doi: 10.1016/j.bmcl.2003.10.029.

DOI:10.1016/j.bmcl.2003.10.029

PMID:14684314

Abstract

The antiproliferative activity of several natural and synthetic flavonoids and some related compounds was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent derivatives were 2'-nitroflavone (14), 2',6-dinitroflavone (15) and the n-buthyl ester of caffeic acid (29). When these compounds were tested in the presence of recombinant human interferon-alpha2b (rhIFN-alpha2b), a cytokine exhibiting an antimitogenic action on WISH cells, an additive effect on cell growth inhibition was observed. Time course studies of the antiproliferative action exerted by the active derivatives or the rhIFN-alpha2b suggested that these compounds induced cell death.

摘要

评估了几种天然和合成黄酮类化合物及一些相关化合物对源自人宫颈癌的细胞系（WISH细胞）的体外抗增殖活性。根据其活性，最有效的衍生物是2'-硝基黄酮（14）、2',6-二硝基黄酮（15）和咖啡酸正丁酯（29）。当在重组人干扰素-α2b（rhIFN-α2b）存在的情况下测试这些化合物时，rhIFN-α2b是一种对WISH细胞具有抗有丝分裂作用的细胞因子，观察到对细胞生长抑制有相加效应。对活性衍生物或rhIFN-α2b发挥的抗增殖作用的时间进程研究表明，这些化合物诱导细胞死亡。