通过延迟钆增强磁共振成像（dGEMRIC）测定的软骨中糖胺聚糖分布：潜在的临床应用。
Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications.
作者信息
Williams Ashley, Gillis Amy, McKenzie Charles, Po Bruce, Sharma Leena, Micheli Lyle, McKeon Brian, Burstein Deborah
机构信息
Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir., Rm. 147, Boston, MA 02115, USA.
出版信息
AJR Am J Roentgenol. 2004 Jan;182(1):167-72. doi: 10.2214/ajr.182.1.1820167.
OBJECTIVE
We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique.
CONCLUSION
The index of glycosaminoglycan distribution, T1(Gd), can exceed 500 msec (denoting high glycosaminoglycan) or can be less than 300 msec, with focal areas as low as 240 msec. Compartmental differences, as well as focal defects within the knee, were observed in patients who had sustained injuries to the ligaments and menisci of the knee or who had chronic osteoarthritis. Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions.
目的
我们试图利用延迟钆增强磁共振成像软骨技术描述一系列膝关节软骨中糖胺聚糖分布的体内观察结果。
结论
糖胺聚糖分布指数T1（钆）可超过500毫秒（表示高糖胺聚糖），也可小于300毫秒，局部区域低至240毫秒。在膝关节韧带和半月板受伤或患有慢性骨关节炎的患者中观察到了膝关节内的区域差异以及局部缺损。总体而言，这些结果表明需要进一步研究疾病进展过程中出现的生化变化以及治疗干预的效果。
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