一种参与细胞内管形成和维持所需的秀丽隐杆线虫CLIC样蛋白。

A C. elegans CLIC-like protein required for intracellular tube formation and maintenance.

作者信息

Berry Katherine L, Bülow Hannes E, Hall David H, Hobert Oliver

机构信息

Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

出版信息

Science. 2003 Dec 19;302(5653):2134-7. doi: 10.1126/science.1087667.

DOI:10.1126/science.1087667

PMID:14684823

Abstract

The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

摘要

秀丽隐杆线虫的排泄管由单个细长且分支的细胞组成，该细胞内部有具有顶端特征的内腔贯穿。exc-4基因缺失会导致这个细胞内管道出现囊性扩张。exc-4编码一种氯化物细胞内通道（CLIC）蛋白家族的成员。EXC-4蛋白定位于不同细胞类型的各种管状膜上，包括排泄管的管腔膜。一个保守的55个氨基酸的结构域使EXC-4能够从细胞质转运到管腔膜。这种膜的管状结构的形成和维持都需要EXC-4。