Simonová Gabriela, Roman Liscák
Department of Stereotactic and Radiation Neurosurgery, Hospital Na Homolce, Prague, Czech Republic.
Expert Rev Anticancer Ther. 2003 Dec;3(6):879-90. doi: 10.1586/14737140.3.6.879.
Brain metastases are an attractive target for radiosurgery. Over a period of 6 years, 400 patients with brain metastases have been treated with radiosurgery. Of these patients, 61% had solitary brain metastases and 39% had multiple brain metastases. Local control was achieved in 90% and improvement of severe neurological symptoms in 76%. The median survival time was 8 months. The significant prognostic factors for survival in patients with solitary brain metastases were age, Karnofsky performance status, severity of symptoms, extent of progressive malignant disease outside the brain, histology, interval between diagnosis of primary tumor and brain metastasis, and minimum applied dosage. The significant prognostic factors in patients with multiple brain metastases were sex, Karnofsky performance status and presence of progressive disease outside the brain.
脑转移瘤是放射外科治疗的一个有吸引力的靶点。在6年的时间里，400例脑转移瘤患者接受了放射外科治疗。在这些患者中，61%有孤立性脑转移瘤，39%有多发脑转移瘤。局部控制率达90%，严重神经症状改善率达76%。中位生存时间为8个月。孤立性脑转移瘤患者生存的重要预后因素包括年龄、卡氏功能状态、症状严重程度、脑外进展性恶性疾病范围、组织学类型、原发肿瘤诊断与脑转移之间的间隔时间以及最小应用剂量。多发脑转移瘤患者的重要预后因素包括性别、卡氏功能状态以及脑外进展性疾病的存在情况。
