抗抑郁药在蓄意自我中毒中的使用：1987年至1997年瑞典隆德地区的精神科诊断及所用药物
Use of antidepressants in deliberate self-poisoning: psychiatric diagnoses and drugs used between 1987 and 1997 in Lund, Sweden.
作者信息
Bäckman Jakob, Ekman Carl-Johan, Alsén Margot, Ekedahl Anders, Träskman-Bendz Lil
机构信息
Dept. of Clinical Neuroscience, Division of Psychiatry, University Hospital, 22185, Lund, Sweden.
出版信息
Soc Psychiatry Psychiatr Epidemiol. 2003 Dec;38(12):684-9. doi: 10.1007/s00127-003-0688-2.
OBJECTIVE
Based on the increased prescription of antidepressants, the aim of this study was to analyse the changes in self-poisonings with antidepressants during the period 1987-1997.
METHODS
A total of 909 patients who were admitted to hospital after deliberate self-poisoning were investigated regarding psychiatric diagnoses and drugs ingested.
RESULTS
In the whole group, there was no significant change in the rate of antidepressant overdoses between 1987 and 1990 (20%) and 1995 and 1997 (17 %), but among females with a mood disorder overdoses decreased from 43% to 22% (p = 0.01). The proportion of selective serotonin reuptake inhibitors (SSRIs) in self-poisonings was significantly lower than expected from sales figures.
CONCLUSION
The increased antidepressant sales have not caused an increased use of antidepressants in self-poisonings. It is, therefore, tempting to assume that an increased use of antidepressants for appropriate indications causes decreased self-poisoning rates.
目的
基于抗抑郁药处方量的增加，本研究旨在分析1987年至1997年期间抗抑郁药自我中毒情况的变化。
方法
对909例因蓄意自我中毒入院的患者进行了精神科诊断和所服药物调查。
结果
在整个研究组中，1987年至1990年（20%）与1995年至1997年（17%）期间抗抑郁药过量服用率无显著变化，但在患有情绪障碍的女性中，过量服用率从43%降至22%（p = 0.01）。自我中毒中选择性5-羟色胺再摄取抑制剂（SSRI）的比例显著低于根据销售数据预期的比例。
结论
抗抑郁药销量的增加并未导致自我中毒中抗抑郁药使用的增加。因此，很容易推测，因适当适应症而增加抗抑郁药的使用会导致自我中毒率降低。
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