Weir P, Ardagh M
Christchurch School of Medicine.
N Z Med J. 1998 Apr 10;111(1063):127-9.
To review the recent epidemiology of deliberate self poisoning presentations to Christchurch Emergency Department and to compare this with 1992 and 1989 data.
A retrospective analysis of case and computer records over the twelve month period of 1996 was conducted and compared with published data for 1992 and 1989.
There were 713 presentations in 1996 to Christchurch Emergency Department with deliberate self poisoning, representing 1.1% (compared with 1.2% 1992; 0.96% 1989) of total presentations. The female to male ratio was 1.9:1.0 (compared with 1.5:1.0, 2.1:1.0). 70.1% of patients presenting were under the age of 35. The principal drugs ingested were antidepressants 20% (compared with 24.4%; 15.7%) paracetamol (16.7% compared with 16.9%; 10.6%) hypnotics/anxiolytics 15.6% (benzodiazepines 11.0% compared with 23.6%; 18.0%), antipsychotics 10.7% (compared with 16.1%; not reported). Gastric decontamination was given to 61% (compared with 73% 1992), charcoal alone used in 54% (compared with 46%; 0.4%), gastric lavage and charcoal 7% (compared with 27%; 78%). 39% received no gastrointestinal decontamination (compared with 27% 1992). Of the patients presenting, 68.9% were admitted (compared with 59%; 66%), 10.2% to Intensive Care Unit (compared with 11%; 18%). There were 6 deaths (compared with 2; 2).
Deliberate self poisoning remains a problem mainly of the young with a gender ratio favouring female. Antidepressant medications, paracetamol, benzodiazepines and antipsychotics remain the most common classes of drugs taken alone or in combination. An important trend within the antidepressants is the increasing misuse of selective serotonin reuptake inhibitors. Rates of admission to hospital and the Intensive Care Unit have changed but mortality rates have had no significant change over the three time periods. Gastrointestinal decontamination techniques employed follow a trend towards the use of activated charcoal and away from gastric lavage.
回顾近期克赖斯特彻奇急诊科蓄意自我中毒就诊情况,并与1992年和1989年的数据进行比较。
对1996年12个月期间的病例和计算机记录进行回顾性分析,并与1992年和1989年公布的数据进行比较。
1996年有713例蓄意自我中毒患者到克赖斯特彻奇急诊科就诊,占总就诊人数的1.1%(1992年为1.2%;1989年为0.96%)。男女比例为1.9∶1.0(1992年为1.5∶1.0,1989年为2.1∶1.0)。就诊患者中70.1%年龄在35岁以下。主要摄入的药物为抗抑郁药20%(1992年为24.4%;1989年为15.7%)、对乙酰氨基酚(16.7%,1992年为16.9%;1989年为10.6%)、催眠药/抗焦虑药15.6%(苯二氮䓬类11.0%,1992年为23.6%;1989年为18.0%)、抗精神病药10.7%(1992年为16.1%;1989年未报告)。61%的患者进行了胃去污处理(1992年为73%),仅使用活性炭的占54%(1992年为46%;1989年为0.4%),洗胃加活性炭的占7%(1992年为27%;1989年为78%)。39%的患者未进行胃肠道去污处理(1992年为27%)。就诊患者中68.9%住院(1992年为59%;1989年为66%),10.2%入住重症监护病房(1992年为11%;1989年为18%)。有6例死亡(1992年为2例;1989年为2例)。
蓄意自我中毒仍然主要是年轻人的问题,性别比例上女性居多。抗抑郁药、对乙酰氨基酚、苯二氮䓬类和抗精神病药仍然是单独或联合服用最常见的药物类别。抗抑郁药中的一个重要趋势是选择性5-羟色胺再摄取抑制剂的滥用增加。三个时间段内住院和入住重症监护病房的比例有所变化,但死亡率没有显著变化。胃肠道去污技术呈现出使用活性炭增多、洗胃减少的趋势。