[Mechanism of the interaction of leukocytes and dermal endothelial cells in cutaneous inflammation].

The infiltration of specific leucocyte populations into inflamed cutaneous tissue is dependent on their interactions with dermal endothelial cells. The dynamic multistep process of vasodilatation, adhesion, transendothelial migration, and penetration through the basal membrane is controlled by a considerable number of soluble mediators and cell adhesion molecules. In this process, dermal endothelium plays a critical role as a gate-keeper who regulates adhesion and penetration of neutrophils, lymphocytes, or monocytes by selection and activation of specific leucocyte subpopulations. In this review, the presently known functions of the involved cell adhesion molecules of the integrin, selectin, and immunoglobulin superfamily, as well as their interactions and their regulation by cytokines and other mediators are summarized.