Detmar M
Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz, Freien Universität Berlin.
Hautarzt. 1992 Nov;43(11):679-86.
The infiltration of specific leucocyte populations into inflamed cutaneous tissue is dependent on their interactions with dermal endothelial cells. The dynamic multistep process of vasodilatation, adhesion, transendothelial migration, and penetration through the basal membrane is controlled by a considerable number of soluble mediators and cell adhesion molecules. In this process, dermal endothelium plays a critical role as a gate-keeper who regulates adhesion and penetration of neutrophils, lymphocytes, or monocytes by selection and activation of specific leucocyte subpopulations. In this review, the presently known functions of the involved cell adhesion molecules of the integrin, selectin, and immunoglobulin superfamily, as well as their interactions and their regulation by cytokines and other mediators are summarized.
特定白细胞群体向炎症性皮肤组织的浸润取决于它们与真皮内皮细胞的相互作用。血管舒张、黏附、跨内皮迁移以及穿过基底膜的动态多步骤过程由大量可溶性介质和细胞黏附分子控制。在这个过程中，真皮内皮作为守门人发挥着关键作用，通过选择和激活特定白细胞亚群来调节中性粒细胞、淋巴细胞或单核细胞的黏附和渗透。在这篇综述中，总结了整合素、选择素和免疫球蛋白超家族中相关细胞黏附分子的目前已知功能，以及它们之间的相互作用以及细胞因子和其他介质对它们的调节作用。
