Heckmann M, Karasek M A, Braun-Falco O
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1991 Nov;42(11):677-83.
Perivascular cell infiltrates with concomitant changes of the endothelium represent a histological hallmark of numerous inflammatory dermatoses. Therefore, the pathophysiology of dermal endothelial cells is of particular importance for the understanding of inflammatory processes within the skin. In recent years, the development and refinement of endothelial cell culture techniques have facilitated investigations in cell biology and molecular biology, which complement histological observations, so leading to sounder knowledge of endothelial cell pathophysiology. The following review will discuss characteristic features of endothelial cells as well as in-vitro culture techniques. Focussing on endothelial cell interactions with leukocytes and with the extracellular matrix, recent developments in this area of research will be presented.
伴有内皮细胞变化的血管周围细胞浸润是众多炎症性皮肤病的组织学特征。因此，真皮内皮细胞的病理生理学对于理解皮肤内的炎症过程尤为重要。近年来，内皮细胞培养技术的发展和完善促进了细胞生物学和分子生物学的研究，这些研究补充了组织学观察结果，从而使我们对内皮细胞病理生理学有了更深入的了解。以下综述将讨论内皮细胞的特征以及体外培养技术。重点关注内皮细胞与白细胞以及与细胞外基质的相互作用，将介绍该研究领域的最新进展。
