Jakubas-Przewłocka J, Sawicki A, Przewłocki P
Department of Mineral Metabolism and Bone Disease, National Food and Nutrition Institute, Warsaw, Poland.
Scand J Rheumatol. 2003;32(5):295-9. doi: 10.1080/03009740310003938.
The aim of the study was to assess bone trabecular structure in postmenopausal and senile osteoporosis.
The study was performed on transiliac specimens obtained from women with postmenopausal (n=10) and senile osteoporosis (n=10) and on normal autopsy bone (n=7). Digitalized microradiographs were analysed using dedicated software allowing for selection of longitudinal and transversal elements.
Significant differences between transversal and control, as well as between longitudinal and control trabecular areas were observed in senile osteoporosis (p<0.005). In postmenopausal osteoporosis, such differences were found for longitudinal trabeculae only (p<0.005). Mean longitudinal trabecular area loss in senile and postmenopausal osteoporosis as compared to control group was 57.2% and 25.7%, respectively. Respective values for transversal trabecular area were 35.0% and 59.4%.
Structural anisotropy of trabecular bone is greater in postmenopausal than in senile osteoporosis and control group. The method developed allows the evaluation of bone structures in radiographs with uneven exposure.
本研究旨在评估绝经后骨质疏松症和老年性骨质疏松症患者的骨小梁结构。
对取自绝经后骨质疏松症患者（n = 10）、老年性骨质疏松症患者（n = 10）的经髂骨标本以及正常尸检骨（n = 7）进行研究。使用专用软件分析数字化显微放射照片，该软件可选择纵向和横向元素。
在老年性骨质疏松症中，观察到横向与对照组之间以及纵向与对照骨小梁面积之间存在显著差异（p < 0.005）。在绝经后骨质疏松症中，仅在纵向骨小梁中发现此类差异（p < 0.005）。与对照组相比，老年性和绝经后骨质疏松症患者的平均纵向骨小梁面积损失分别为57.2%和25.7%。横向骨小梁面积的相应值分别为35.0%和59.4%。
绝经后骨质疏松症患者骨小梁的结构各向异性大于老年性骨质疏松症患者和对照组。所开发的方法能够评估曝光不均匀的X线照片中的骨结构。
