一名患有X连锁无丙种球蛋白血症（布鲁顿病）的患者发生幼年型银屑病关节炎。

Juvenile onset psoriatic arthritis in a patient with X-linked agammaglobulinemia (Bruton's disease).

作者信息

Palazzi C, D'Amico E, Cacciatore P, Pennese E, Petricca A, Olivieri I

机构信息

Division of Rheumatology, Villa Pini Clinic, Chieti, Italy.

出版信息

Scand J Rheumatol. 2003;32(5):309-11. doi: 10.1080/03009740310003965.

DOI:10.1080/03009740310003965

PMID:14690146

Abstract

We describe a 47-year-old male patient suffering from X-linked (or Bruton's) agammaglobulinemia with severe psoriatic arthritis (PsA), which started in childhood. PsA has been previously described in T-cell defective disorders, such as HIV infection, but our observation demonstrates that this rheumatic disease can also occur in subjects with B-lymphocyte cell functional impairment. Chronic inflammatory (bacterial?) involvement of the bowel could represent a pathogenetic connection between X-linked agammaglobulinemia and PsA.

摘要

我们描述了一名47岁男性患者，患有X连锁（或布鲁顿氏）无丙种球蛋白血症，并伴有严重的银屑病关节炎（PsA），该病始于童年时期。PsA此前已在T细胞缺陷性疾病（如HIV感染）中有所描述，但我们的观察表明，这种风湿性疾病也可能发生在B淋巴细胞功能受损的患者中。肠道的慢性炎症（细菌性？）累及可能代表了X连锁无丙种球蛋白血症与PsA之间的发病机制联系。