Ledda M, Barni L, Altieri L, Pannese E
Institute of Histology, Embryology and Neurocytology, University of Milan, Italy.
J Submicrosc Cytol Pathol. 2003 Jul;35(3):267-70.
We studied the Golgi apparatus in the satellite cell sheaths enveloping spinal ganglion neurons of rabbits aged 12, 42, and 79 months. We found neither structural changes nor indications of peripheral displacement of this organelle with advancing age. The mean percentage of cytoplasmic volume occupied by the Golgi apparatus decreased significantly passing from young adult to old rabbits. This decrease was only in very minor part a consequence of lipofuscin accumulation, so that the ratio between the total volume of the Golgi apparatus and the functionally active volume of cytoplasm decreased with age. The mean cytoplasmic volume of perineuronal satellite cell sheaths did not change significantly with increasing age, whereas the total volume of the Golgi apparatus within these sheaths decreased significantly with age. This decrease strongly suggests that the activity of satellite cells diminishes in old age, further suggesting that these cells are unable to compensate for the decrease in the neuronal metabolism that a number of authors have described in old age.
我们研究了包裹12个月、42个月和79个月龄兔脊髓神经节神经元的卫星细胞鞘中的高尔基体。我们发现，随着年龄增长，该细胞器既无结构变化，也无外周移位迹象。从成年青年兔到老年兔，高尔基体所占细胞质体积的平均百分比显著下降。这种下降仅有极小部分是脂褐素积累的结果，因此高尔基体总体积与细胞质功能活性体积之比随年龄下降。神经周卫星细胞鞘的平均细胞质体积并未随年龄增长而显著变化，而这些鞘内高尔基体的总体积却随年龄显著减少。这种减少强烈表明，老年时卫星细胞的活性降低，进一步表明这些细胞无法补偿许多作者所描述的老年时神经元代谢的下降。
